Serotonin, 5HT1 agonists, and migraine
نویسندگان
چکیده
منابع مشابه
Serotonin and CGRP in Migraine
Migraine is defined as recurrent attack of headache that are commonly unilateral and accompanied by gastrointestinal and visual disorders. Migraine is more prevalent in females than males with a ratio of 3:1. It is primarily a complex neurovascular disorder involving local vasodilation of intracranial, extracerebral blood vessels and simultaneous stimulation of surrounding trigeminal sensory ne...
متن کاملSerotonin receptor agonists in the acute treatment of migraine: a review on their therapeutic potential
Migraine is an important socioeconomic burden and is ranked the sixth cause of years of life lost because of disability in the general population and the third cause of years of life lost in people younger than 50 years. The cornerstone of pharmacological treatment is represented by the acute therapy. The serotonin (5-hydroxytryptamine [5-HT]) receptor subtype 1B/1D agonists, called triptans, a...
متن کاملTriptans (serotonin, 5-HT1B/1D agonists) in migraine: detailed results and methods of a meta-analysis of 53 trials.
The triptans, selective serotonin 5-HT1B/1D agonists, are very effective acute migraine drugs. Soon, seven different triptans will be clinically available at 13 different oral doses, making evidence-based selection guidelines necessary. Triptan trials have similar designs, facilitating meta-analysis. We wished to provide an evidence-based foundation for using triptans in clinical practice, and ...
متن کاملEffect of serotonin in migraine patients.
LITTLE is known of the factors that predispose to migraine or the biochemical events that initiate the disturbances characteristic of this condition. Earlier studies by Marcussen and Wolffl have shown that an initial phase of vasoconstriction is responsible for the prodroma1 symptoms, while the pain follows a marked distention of cranial vessels that are temporarily hypotonic. They also have pr...
متن کاملOral triptans (serotonin 5-HT(1B/1D) agonists) in acute migraine treatment: a meta-analysis of 53 trials.
BACKGROUND The triptans, selective serotonin 5-HT(1B/1D) agonists, are very effective acute migraine drugs with a well- developed scientific rationale. Seven different triptans will soon be clinically available, making evidence-based selection guidelines necessary. Triptan trials have similar designs, facilitating meta-analysis; this will provide a foundation for using triptans in clinical prac...
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ژورنال
عنوان ژورنال: Current Opinion in Supportive & Palliative Care
سال: 2014
ISSN: 1751-4258
DOI: 10.1097/spc.0000000000000044